Some Major Steps in the Understanding of the Chemistry and Biochemistry of Chl - Chlorophyll Biosynthesis and Technological Applications - page 11

1.2.14 Bogorad and Granick, 1953a
In 1953, Bogorad and Granick described a Chlorella mutant capable of
accumulating porphyrins with two, three, four, five, six, seven and eight carboxyl
groups, and proposed that these porphyrins may be intermediates in the formation
of DV Proto (Bogorad and Granick 1953a ).
1.2.15 Bogorad and Granick, 1953b
In 1953, Bogorad and Granick demonstrated the conversion of exogenous PBG to
DV Proto in frozen and thawed Chlorella cells, and proposed a single branched
paper chemistry pathway that originated in glycine and succinate and ended with
the formation of Proto via ALA, Uroporphyrin III (Uro), Coproporphyrin III
(Copro), hematoporphyrin IX, and DV Proto (Bogorad and Granick 1953b ).
1.2.16 Granick, 1954
In 1954, Granick, demonstrated the conversion of ALA to PBG and porphyrins by
extracts of Chlorella cells, of spinach and chicken erythrocytes (Granick 1954 ).
1.2.17 Smith and Benitez
In 1954, Smith and Benitez, described the kinetics of Pchl a (actually mainly
Pchlide a ) photoconversion to chlorophyll(ide) [Chl(ide)] a in etiolated barley
leaves. At the time Smith and Benitez believed that they were converting Pchl
into Chl (Smith and Benitez 1954 ).
1.2.18 Neve and Labbe, 1956
In 1956, Neve and Labbe, recognized that the actual tetrapyrrole intermediates
between PBG and DV proto are not porphyrins but reduced porphyrins, namely
porphyrinogens, i.e. hexahydro porphyrins (Neve and Labbe 1956 ).