Biology Reference
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1.1.29 Cookson and Rimington, 1954
In 1954, Cookson and Rimington finalized their investigations of the chemical
structure of porphobilinogen (Cookson and Rimington 1954 ). Porphobilinogen is
the precursor of Uroporphyrinogen III, the first tetrapyrrole precursor of heme
and Chl.
1.1.30 Holt and Morley, 1959
In 1959, Holt and Morley determined the chemical structure of Chl d (Holt and
Morley 1959 ).
1.1.31 Woodward and Coworkers, 1960
In 1960, Woodward and coworkers reported the total synthesis of chlorin e 6
trimethyl ester, an important degradation product of chl. Since the reactions
between chlorin e 6 trimethyl ester and Chl had been supposedly worked out earlier
(in 1913) by Willstatter and coworkers, it was erroneously assumed that Woodward
had achieved the total synthesis of Chl. In the process of their work the authors
discovered the remarkable susceptibility of Chl to electrophilic attack. Woodward
was Awarded the Nobel Prize for his work on Chl.
1.1.32 Closs and Coworkers, and Katz and Coworkers, 1963
In 1963, Closs and coworkers and Katz and coworkers, applied infra-red and
nuclear magnetic resonance techniques to the study of Chl and some of its
derivatives (Closs et al. 1963 ; Katz et al. 1963 ).
1.1.33 Dougherty and Coworkers, 1970
In 1970, Dougherty et al., determined the chemical structure of Chl c (Dougherty
et al. 1970 ).
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