Biology Reference
In-Depth Information
Chapter 13
The Chl b Biosynthetic Pathway:
Intermediary Metabolism
The time continuum consists of the past present and future.
Understanding the past is essential for a better
understanding of the present and future. Technology can help
solve the problems of the present. However understanding
the forces that control and regulate the physical and
biological components of the universe is mandatory for the
development of future technologies (C. A. Rebeiz).
13.1
Introduction
13.1.1 Determination of Precursor-Product Relationships
In Vivo
In discussing the Chl
b
biosynthetic pathway, use will be made of kinetic analysis of
precursor-product relationships in vivo. In 1988, equations were derived to investi-
gate possible precursor-product relationships in branched, and interconnected
pathways (Rebeiz et al.
1988
; Tripathy and Rebeiz
1988
). It was shown that for
any two compounds A and B, formed from a common precursor P such as ALA,
and having a possible direct precursor-product relationship between them, for any
number of time intervals t
1
to t
2
, the following equation describes the relationship
between the specific radioactivity of compound A, possible radiolabel incorpo-
ration from compound A into compound B, and the net synthesis of compound
B from compound A (Rebeiz et al.
1988
):
QB
2
¼ð
A
1
þ
A
2
Þ
=
Þð
B
2
Þ
2
(13.1)
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