The Discovery of Piragliatin, a Glucokinase Activator - Accounts in Drug Discovery Case Studies in Medicinal Chemistry - page 62

Table 3.4 Rat pharmacokinetics data for compounds 2a and 9a.
Cpd

Dose (mg kg 1 ) Cl (mL kg 1 h 1 ) ss (mL kg 1 ) AUC 0-inf (ng hmL 1 ) max (mgmL 1 ) max (h) Route F po (%)

2a 5 iv 2609 4211 1877 - - -

10 po - - 455 133 1.4 12

30 po - - 1464 471 3.3 13

9a 5 iv 1800 2160 2774 - - -

10 po - - 5150 1140 3.3 92.8

30 po - - 51748 4302 4.7 311