A Case History on the Challenges of Central Nervous System and Dual Pharmacology Drug Discovery - Accounts in Drug Discovery Case Studies in Medicinal Chemistry - page 275

Piperazine series Aminopyrrolidine series

4.5

5

4

4.5

3.5

4

3.5 3

3

2.5

2.5

2

2

50 100 150 200

0 50 100 150 200 250 300 350 400 0

NRI IC50

NRI IC50

Figure 12.7 NA potency and clog P relationship for piperazine and aminopyrrolidine series.