Chemistry Reference
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Table 7.1 Activities and physicochemical properties of substituted tetrahydronaphthalenes
R
1
NHMe
R
2
R
3
3, 6-24
Cl
Cl
TPSA (A
˚
2
)
R
1
R
2
R
3
SRI (nM)
a
DRI (nM)
a
NRI (nM)
a
Cpd
clog P
log D
3
H
H
H
3
310
825
12
5.4
3.1
6
CO
2
H
H
H
31
540
880
49
2.8
-
7
CONH
2
H
H
8
290
1150
55
3.9
-
8
CONHMe
H
H
31
420
1500
41
4.1
-
9
H
CO
2
H
H
90
-
-
49
2.8
-
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