Biology Reference
In-Depth Information
References
1. Lee Y, Ahn C, Han J et al (2003) The nuclear
RNase III Drosha initiates microRNA process-
ing. Nature 425:415-419
2. Denli AM, Tops BB, Plasterk RH et al (2004)
Processing of primary microRNAs by the
microprocessor
17. Sakamoto S, Aoki K, Higuchi T et al (2009)
The NF90-NF45 complex functions as a nega-
tive regulator in the microRNA processing
pathway. Mol Cell Biol 29:3754-3769
18. Michlewski G, Caceres JF (2010) Antagonistic
role of hnRNP A1 and KSRP in the regulation
of let-7a biogenesis. Nat Struct Mol Biol
17:1011-1018
19. Zeng Y, Cullen BR (2005) Efficient processing
of primary microRNA hairpins by Drosha
requires flanking nonstructured RNA
sequences. J Biol Chem 280:27595-27603
20. Yeom KH, Lee Y, Han J et al (2006)
Characterization of DGCR8/Pasha, the essen-
tial cofactor for Drosha in primary miRNA pro-
cessing. Nucleic Acids Res 34:4622-4629
21. Sohn SY, Bae WJ, Kim JJ et al (2007) Crystal
structure of human DGCR8 core. Nat Struct
Mol Biol 14:847-853
22. Faller M, Toso D, Matsunaga M et al (2010)
DGCR8 recognizes primary transcripts of
microRNAs through highly cooperative bind-
ing and formation of higher-order structures.
RNA 16:1570-1583
23. Guo F (2012) Drosha and DGCR8 in
microRNA biogenesis. In: Guo F, Tamanoi F
(eds) The enzymes: eukaryotic RNases and
their partners in RNA degradation and biogen-
esis, Part B, vol 32, 1st edn. Elsevier Academic
Press, Amsterdam, Netherlands, pp. 101-121
24. Lee Y, Jeon K, Lee JT et al (2002) MicroRNA
maturation: stepwise processing and subcellular
localization. EMBO J 21:4663-4670
25. Newman MA, Thomson JM, Hammond SM
(2008) Lin-28 interaction with the Let-7 pre-
cursor loop mediates regulated microRNA pro-
cessing. RNA 14:1539-1549
26. Lee Y, Kim VN (2007) In vitro and in vivo
assays for the activity of Drosha complex.
Methods Enzymol 427:89-106
27. Zeng Y, Yi R, Cullen BR (2005) Recognition
and cleavage of primary microRNA precursors
by the nuclear processing enzyme Drosha.
EMBO J 24:138-148
28. Zhang X, Zeng Y (2010) The terminal loop
region controls microRNA processing by
Drosha and Dicer. Nucleic Acids Res 38:
7689-7697
29. Senturia R, Faller M, Yin S et al (2010)
Structure of the dimerization domain of
DiGeorge Critical Region 8. Protein Sci 19:
1354-1365
30. Senturia R, Laganowsky A, Barr I et al (2012)
Dimerization and heme binding are conserved
in amphibian and starfish homologues of the
microRNA processing protein DGCR8. PLoS
One
complex.
Nature
432:
231-235
3. Gregory RI, Yan KP, Amuthan G et al (2004)
The microprocessor complex mediates the gen-
esis of microRNAs. Nature 432:235-240
4. Faller M, Matsunaga M, Yin S et al (2007)
Heme is involved in microRNA processing.
Nat Struct Mol Biol 14:23-29
5. Barr I, Smith AT, Senturia R et al (2011)
DiGeorge critical region 8 (DGCR8) is a dou-
ble-cysteine-ligated heme protein. J Biol Chem
286:16716-16725
6. Barr I, Smith AT, Chen Y et al (2012) Ferric,
not ferrous, heme activates RNA-binding
protein DGCR8 for primary microRNA
processing. Proc Natl Acad Sci U S A
109:1919-1924
7. Wang Y, Medvid R, Melton C et al (2007)
DGCR8 is essential for microRNA biogenesis
and silencing of embryonic stem cell self-
renewal. Nat Genet 39:380-385
8. Yi R, Pasolli HA, Landthaler M et al (2009)
DGCR8-dependent microRNA biogenesis is
essential for skin development. Proc Natl Acad
Sci U S A 106:498-502
9. Faller M, Guo F (2008) MicroRNA biogenesis:
there's more than one way to skin a cat.
Biochim Biophys Acta 1779:663-667
10. Han J, Lee Y, Yeom KH et al (2004) The
Drosha-DGCR8 complex in primary microRNA
processing. Genes Dev 18:3016-3027
11. Fukuda T, Yamagata K, Fujiyama S et al (2007)
DEAD-box RNA helicase subunits of the
Drosha complex are required for processing of
rRNA and a subset of microRNAs. Nat Cell
Biol 9:604-611
12. Guil S, Caceres JF (2007) The multifunctional
RNA-binding protein hnRNP A1 is required
for processing of miR-18a. Nat Struct Mol Biol
14:591-596
13. Viswanathan SR, Daley GQ, Gregory RI
(2008) Selective blockade of microRNA pro-
cessing by Lin28. Science 320:97-100
14. Davis BN, Hilyard AC, Lagna G et al (2008)
SMAD proteins control DROSHA-mediated
microRNA maturation. Nature 454:56-61
15. Trabucchi M, Briata P, Garcia-Mayoral M et al
(2009) The RNA-binding protein KSRP pro-
motes the biogenesis of a subset of microR-
NAs. Nature 459:1010-1014
16. Suzuki HI, Yamagata K, Sugimoto K et al
(2009) Modulation of microRNA processing
by p53. Nature 460:529-533
7(7):e39688.
doi:
10.1371/journal.
