Biomedical Engineering Reference
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not the mixture of HA and PEI but the HA-PEI conjugate [22]. They
also managed to determine the percentage of the carboxyl groups of
HA that were modified with PEI (
Figure 3.2
).
a
b
(1)
(2)
(3)
(4)
ppm
0.00
2.00
4.00
6.00
8.00 10.00
Time (min)
12.00
14.00
16.00
18.00
20.00
5
4
3
2
1
0
Figure 3.2
GPC and
1
H-NMR of HA, PEI and HA derivatives.
GPC for HA at left peak and PEI-HA conjugate at right peak
detected at 210 nm (a); The
1
H-NMR spectra of HA (1), branched
PEI (2), a mixture of branched PEI and HA (3) and PEI-HA
conjugate (4) synthesised with a feeding of weight ratio of HA to
PEI 1:2 (b). Adapted from from G. Jiang, K. Park, J. Kim,
K.S Kim, E.J Oh, H. Kang, S.E Han, Y.K Oh, T.G Park and
S.K Hahn,
Biopolymers
, 2008,
89
, 7, 635 [22]
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