Hyaluronic Acid Incorporation into Scaffolds for Bone and Cartilage Regeneration - Hyaluronic Acid for Biomedical and Pharmaceutical Applications - page 44

This same material has also been used to treat infrabony periodontal
defects, with a reduction in probing pocket depth and an increase
in clinical attachment level after one year [126, 127]. Radiographic
evaluation further indicated mild bone remodelling at six months and
satisfactory infrabone filling after 24 months [127]. An HA carrier
has also been used with a synthetic peptide derived from collagen
(PepGen P-15 putty). When combined with bovine hydroxyapatite
in clinical sinus augmentation procedures, increases in new bone
formation [128] and bone mineral density [129] were observed.

2.10 Conclusions

This chapter has reviewed the state of the art for the incorporation
of HA into scaffolds for bone and cartilage repair. Many in vitro
and in vivo studies have demonstrated a positive effect of HA on
chondrogenesis and osteogenesis, either alone; in combination with
cells, growth factors, calcium phosphate, and/or other polymers;
or as an implant coating, suggesting that HA may be an interesting
biomaterial for these applications. Additionally, the availability of
clinical grade hyaluronic acids could facilitate use of these materials
in human patients suffering from cartilage damage or degradation
as well as non-healing bone fractures. We envision that research on
the use of HA for bone and cartilage regeneration will continue to
grow in the coming years.

References

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2. J.A. Buckwalter and H.J. Mankin, Instructional Course

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3. A.M. Bhosale and J.B. Richardson, British Medical Bulletin ,

2008, 87 , 77.