Biomedical Engineering Reference
In-Depth Information
Figure 2.2
Examples of various scaffold structures that can be
produced from HA or blends with other polymers. Scale bars: (a)
20; (b) 100; and (c) 250 µm. (a) Electrospun, pure methacrylated
HA fibres. Reproduced with permission from I.L. Kim, R.L.
Mauck and J.A. Burdick,
Biomaterials
, 2011,
32
, 34, 8771.
©2011, Elsevier [4]; (b) sponge-like scaffold of HA combined with
PLGA made by gas foaming and EDC crosslinking. Reproduced
with permission from H.S. Yoo, E.A. Lee, J.J. Yoon and T.G.
Park,
Biomaterials
, 2005,
26
, 14, 1925. ©2005, Elsevier [50];
and (c) fibrous network of HA combined with chitosan formed
via
wet spinning. Reproduced with permission from S. Yamane,
N. Iwasaki, T. Majima, T. Funakoshi, T. Masuko, K. Harada, A.
Minami, K. Monde and S. Nishimura,
Biomaterials
, 2005,
26
,
6,
611. ©2005, Elsevier [55]
2.5.1 Delivery of Chondrocytes
As the primary cell type in articular cartilage, chondrocytes are a
potential cell source for the creation of cartilage tissue engineering
constructs. Chick chondrocytes embedded in HA carriers led to
better regeneration of hyaline cartilage in articular cartilage and
subchondral bone defects of old chickens when compared to empty
carriers or no treatment [57]. Following this initial demonstration of
efficacy, other studies displayed the positive effects of HA scaffolds on
the phenotype and matrix synthesis of chondrocytes [57-60]. Porcine
chondrocytes encapsulated in photocrosslinked hydrogels made
from methacrylated HA maintained their phenotype and produced
Search WWH ::
Custom Search