Biomedical Engineering Reference
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HO
HO
OH
(A)
(B)
O
OH
HO
HO
O
O
O
OH
N
N
NH
N
OH
H
H
O
O
O
OH
HO
O
HO
HN
O
N
HO
HO
OH
OH
OH
OH
OH
O
O
O
O
HN
N
HO
HO
O
O
O
O
O
O
O
O
O
O
N
N
N
O
H
H
H
O
O
N
ADH-gel
ODH-gel
HO
HO
OH
120*
(C)
OH
(D)
120
O
H
O
90
N
100
80
60
40
20
0
O
N
H
O
HO
OH
O
HN
N
38
HO
HO
OH
OH
O
O
O
14
12
8
1.5
2.5
6
O
H
H
O
N
O
O
O
O
N
pH 5.0
pH 7.4
pH 9.0
H
ADH-gel
ODH-gel
CDH-gel
CDH-gel
Figure 8.3
Tuning hydrazone stability by delocalising electronic
charges, resulting in exceptional stability at different pH.
The chemical structure of (A) Adipic acid dihydrazide hydrogel or
ADH-gel (B) oxalyl dihydrazide hydrogel or ODH-gel
(C) Carbodihydrazide hydrogel or CDH-gel (D) their stability in
days under different pH conditions. ODH: oxalic dihydrazide.
Reproduced with permission from O.P. Oommen, S. Wang,
M. Kisiel, M. Sloff, J. Hilborn and O.P. Varghese,
Advanced
Functional Materials
, 2013,
23
, 10, 1273. ©2013, John Wiley &
Sons [25]
8.6.1 Hyaluronic Acid Hydrogel for Drug/Protein Delivery
HA hydrogel is another interesting vehicle for drug delivery. Ito
and co-workers synthesised an injectable HA hydrogel for anti-
inflammatory drug delivery. In their research dexamethasone-
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