Biomedical Engineering Reference
In-Depth Information
Table 8.1 Overview of biomedical applications of HA
Type of HA
Application
Ester-containing HA
Adipose tissue
Hydrazide/aldehyde-containing HA; HA/PVA; and
matrix metalloproteinase-sensitive HA
Bone
HA/collagen I; HA/gelatin/chondoitin-6-sulfate;
adipic dihydrazide-modified collagen/HA; fibrin/HA;
chitosan/HA; and carrageenan/fibrin/HA
Cartilage
Thiolated HA/PEG diacrylate; HA/gelatin gradient;
poly(
N
-isopropylacrylamide)/HA; HA/pendant
L-benzoyl-cysteine; methacrylated-HA; collagen/HA/
chitosan; collagen/HA; and silk fibroin/HA
General
Acryl-modified HA/PEG acryl
Gene therapy
Ester-modified HA/butyric and retinoic acid; and
methacrylated-HA/divinylsulfone modified-HA
Heart
Benzyl ester modified-HA; and HA/gelatin/
chondoitin-6-sulfate
Intervertebral
disc
Benzyl ester modified-HA;
Liver
HA
Muscle
Photocrosslinked HA; collagen/HA; fibroin/HA;
antibody-modified HA; and HA/polylysine
Nerve
HA derivatives and carbodiimide-crosslinked HA
Ophthalmology
Benzyl ester modified-HA; HA-gelatin; EDC
crosslinked HA/chondoitin-6-sulfate/gelatin;
adipic dihydrazide derivatives of HA/PEG-
propiondialdehyde; and HA/chitosan/gelatin
Skin
Thiol-modified HA
Spinal cord
Methacrylated-HA
Vascular tissue
PVA: Polyvinyl alcohol
Reproduced with permission from S. Van Vlierberghe, P. Dubruel and
E. Schacht,
Biomacromolecules
, 2011,
12
, 5, 1387. ©2011, American
Chemical Society [47]
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