BIOMEDICAL APPLICATIONS I: DELIVERY OF DRUGS - Carbon Nanotubes: From Bench Chemistry to Promising Biomedical Applications - page 25

Table 2.1 Functionalisations of carbon nanotubes (CNTs) and their use as drug
delivery systems (DDS) a

CNTs Diam. Functionalisation Therapeutic

agents
incorporated

Applications Ref.

pSWCNTs ~1 nm 1-pyrenebutanoic acid,

succinimidyl ester onto
CNTs

Proteins
(ferritin and
streptavidin)

Cancer therapy (56)

(75)

Amphiphilic (PEG)-based
copolymer

Doxorubicin
(DOX)

Cancer therapy

(76)

Copolymer Pluronic F127 Doxorubicin

(DOX)
Erythropoietin
(EPO)

Cancer therapy

(77)

PEG-8 caprylic/capric
glycerides

Anaemia

(78)

Phospholipid (PL)-folic
acid (FA) copolymer + NIR

— Carcer therapy

(79)

—
PEG-platinum(IV) construct

DNA
Prodrug Pt(IV)

Gene therapy
Cancer therapy (80)

SWCNTs-
ox

~1 nm,
shorter
tubes

SWCNTs-CONH-C 6 H 12 NH 3 + siRNA Cancer therapy (81)

pMWCNTs 10-50

nm

Copolymer Pluronic F127 Doxorubicin

(DOX)

Cancer therapy (76)

SWCNTs-
ox

~1 nm,
shorter
tubes

Oxidation + EDC + Biotin/
Streptavidin

Streptavidin Cancer therapy (121)

Immunohis-
tochemistry,
enzyme stabili-
sation
Gene therapy

(82)

Oxidation + carbodiimide
(EDAC)

BSA

(83,
84) Oxidation + EDC DNA

MWCNTs-
ox

10-50,
shorter
tubes

Oxidation + carbodiimide
(EDAC)

BSA Immunohisto-

chemistry, enzy-
me stabilisation

(83)

Gonadotropin-
releasing
hormone

Oxidation + EDC + NHS

Cancer therapy (85)