Biomedical Engineering Reference
In-Depth Information
Initially, pristine MWCNTs underwent the 1,3-dipolar cycloaddition of
azomethine ylides, forming the zeroth-generation (G0) dendron-MWCNTs.
This was followed by incorporation of ethylenediamine and methyl acrylate
in a divergent approach (Fig. 5.32), thus deriving generations G1 and G2.
HO
N
Cl
-
NH
2
NH
O
O
O
O
N
N
O
N
Cl
-
G0
46
N
N
N
N
O
O
O
O
O
O
45
47
O
O
H
2
N
HN
HO
H
2
N
HN
N
Cl
-
HO
N
Cl
-
O
OH
Cl
-
NH
48
N
N
OMe
Cl
-
NH
2
HO
HN
N
H
2
N
NH
2
O
49
N
NH
NH
O
O
O
N
O
N
O
HN
N
O
Cl
-
G1
46
N
NH
2
N
N
N
O
O
O
O
O
N
O
O
50
HN
HN
G2
O
N
N
HN
O
O
O
O
NH
51
HN
NH
2
O
O
H
2
N
HN
OH
N
HN
N
Cl
-
O
O
NH
NH
O
O
NH
N
Cl
-
NH
OH
HO
OH
N
N
Cl
-
O
N
Cl
-
Figure 5.32
Schematic representation of MWCNT-PAMAM dendrons.
Accordingly, a progressive increase in the tubes' diameter was observed
as the dendritic structure grew. The luorescently labelled siRNA was
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