BIOMEDICAL APPLICATIONS IV: CARBON NANOTUBE-NUCLEIC ACID COMPLEXES FOR BIOSENSORS, GENE DELIVERY AND SELECTIVE CANCER THERAPY - Carbon Nanotubes: From Bench Chemistry to Promising Biomedical Applications - page 115

COOH

HOOC

COO H

COOH

HOOC

HOOC COOH

HOOC

COOH COOH

HOOC

COOH

O

20

COOH

HOO C COOH

HN

NH2

EDC G

G

G

G

T T

T

T G

G

G Sulfo-N HS

G

T T

T

T

G

G T

T

G T

G T

21 22

Figure 5.13 Conjugation of DNA-wrapped SWCNTs and COOH-QDs. Abbreviations :
EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; sulfo-NHS,
sulfo- N -hydroxysuccinimide.

Figure 5.14. (A) Fluorescence image of a DNA-SWCNT/QD conjugate and (B) spectra
from different sample locations (a-c). (C) Fluorescence spectra from unconjugated QDs
and QDs physisorbed onto DNA-SWCNTs. (D) Fluorescence spectra from unconjugated
QDs, DNA-conjugated QDs in the absence of SWCNTs, and DNA-SWCNT/QD conjugates.
Reproduced from Zhou et al. 41 with permission. See also Colour Insert.