Biomedical Engineering Reference
In-Depth Information
N-hydroxy-
succinimide
(N HS)
O
O
O
PNA
N
HO
O
O
5
6
PNA
O
H
N
H
N
H
2
N
Glu
N
N
N
N
H
O
O
G
O
G
O
T
O
C
C
A
O
O
O
O
O
P
O
P
O
O
O
OH
O
-
O
-
cDNA
7
Figure 5.8
A cDNA fragment with a single-stranded, “sticky” end hybridised by
Watson-Crick base pairing to the PNA-CNT.
Another supramolecular complex, based on the combination of SWCNTs
with anthrylcyclodextrin (ACD) and poly-pseudorotaxane (PPR) (Fig. 5.9),
was shown to cleave dsDNA under visible light radiation.
33
The success of the
ensemble was guaranteed by the natural tendency of the cyclodextrins (CDs)
to adhere to CNTs and the ability of the anthryl group to intercalate within
the DNA's groove.
1
8
9
10
8
9
Figure 5.9
Preparation of a SWCNT-ACD-PPR conjugate and its DNA wrapping. See
also Colour Insert.
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