Biomedical Engineering Reference
In-Depth Information
CHAPTER 5
Nanobiosensors
Chapter Outline
5.1 Introduction 95
5.2 Optical DNA Detection by Multifunctional Cross-Linked Au Nanoaggregates
( Li et al., 2009 ) 97
5.3 High-performance Multiplexed Determination of Proteins: Determinations of Cancer
Biomarkers in Serum and Saliva Using QD Bioconjugate Labels ( Jokerst et al., 2009 ) 99
5.4 Carbon Nanofiber Paste Electrode Nonenzymatic Glucose Sensor ( Liu et al., 2009 ) 101
5.5 Use of gold Nanoparticles in a Sensitive Immunochromatographic Assay for the
Detection of PSA in Serum ( Nagatani et al., 2006 ) 104
5.6 In Vitro Characterization of an Intracellular Nanosensor for ROS ( Henderson et al.,
2009 ) 105
5.7 Combined Fluorescence and SERS Molecular Beacon Assay to Detect Human Viral
RNA (Sha et al., 2007) 107
5.8 Nanotube-based Biosensor for the Detection of Disease-Specific Autoantibodies
in Human Serum (Drouvalakis et al., 2008) 109
5.9 Gold Nanoparticle Amperometric Immunosensor (biosensor) for OPG
( Singh et al., 2008 ) 111
5.10 Label-Free Antigen-Antibody Binding on a Gold Nanoparticle Sensor Array
( Olkhov and Shaw, 2008 ) 113
5.11 Electrochemical Immunosensing Using Magnetic Beads and Gold Nanocatalysts
(Selvaraju et al., 2007) 116
5.12 Conclusions 118
5.1 Introduction
Nanotechnology and its applications in diverse areas have recently generated tremendous interest;
utilizing this advantage is the focus of research by different groups throughout the world. In this
chapter we present briefly the application of nanotechnology in different biosensor applications,
and indicate the advantages of enhancing the biosensor parameters such as sensitivity, selectivity,
economics, and response time. Some of the examples presented and analyzed include:
(a) Multifunction cross-linked Au nanoaggregates for optical DNA detection ( Li et al.,
2009 ).
 
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