Biomedical Engineering Reference
In-Depth Information
signal is a superposition of independent parallel reactions occurring on the biosensor surface.
These parallel binding reactions result from a continuous distribution of thermodynamic and
kinetic binding constants. In a more recent publication, Svitel et al. (2007) have expanded
their computational model and their approach to include a compartment-like transport step,
which describes the competitive binding to different surface sites in a zone of depleted ana-
lyte close to the biosensor surface. Just as in the fractal analysis approach presented in differ-
ent chapters in the topic to analyze the binding and the dissociation phase, the approach
presented by Svitel et al. (2007) helps to analyze surface binding when both inhomogeneity
on the biosensor surface and transport limitations are present simultaneously. Their approach,
the authors claim, permits the evaluation of both the kinetic binding parameters as well as the
effective transport rate coefficients.
References
Anderson J, NIH Panel Review Meeting, Case Western Reserve University, Cleveland, OH, July 1993.
Berland KM, PTC So, and E Gratton, Two-photon fluorescence correlation spectroscopy: Method and application
to the intracellular environment, Biophysical Journal , 68 , 694-701 (1995).
Chaudhari A, CC Yan, and SL Lee, Multifractal analysis of diffusion-limited reactions over surfaces of diffusion-
limited aggregates, Chemical Physics Letters , 207 , 220-226 (2002).
Chaudhari A, CC Yan, and SL Lee, Mathematical and general, Journal of Physics A , 36 , 3757 (2003).
Cooper MA, Optical biosensors in drug discovery, National Reviews in Drug Discovery , 1 , 515-528 (2002).
Coppens MO and GF Froment, Diffusion and reaction in a fractal catalyst pore. Geometrical aspects, Chemical
Engineering Science , 50 (6), 1013-1026 (1995).
Corel Quattro Pro, 8.0, Corel Corporation Limited, Ottawa, Canada, 1997.
De Gennes PG, Diffusion-controlled reactions, Polymer Melts Radiation and Physical Chemistry , 22 , 193 (1982).
Dewey TG and JG Bann, Diffusion-controlled reaction in polymer melts, Biophysical Journal , 63 , 594 (1992).
Ekinci KL and MN Roukes, Nanoelectrical systems, Reviews of Scientific Instrumentation , 76 , 1-12 (2005).
Fatin-Rouge N, K Starchev, and J Buffle, Size effects on diffusion process with agarose gels, Biophysical Journal ,
86 , 2710-2719 (2004).
Federov BA, BB Federov, and PW Schmidt, An analysis of the fractal properties of globular proteins, Journal of
Chemical Physics , 99 , 4076-4083 (1999).
Giona M, First-order reaction-diffusion in complex fractal media, Chemical Engineering Science , 47 , 1503-1515
(1992).
Ghosh RN and WW Webb Results of automated tracking of low density lipoprotein receptors on cell surfaces,
Biophysical Journal , 53 , A352 (1988).
Glaser RW and X Hausdorf Binding kinetics of an antibody against HIV p24 core protein measured with real-time
biomolecular interaction analysis suggest a slow conformational exchange in antigen p24, Journal of
Immunological Methods , 189 , 1-14 (1996).
Harder FH, S Havlin, and A Bunde, Diffusion in fractals with singular waiting-time distribution, Physics Reviews
B , 36 , 3874-3879 (1987).
Havlin S, Molecular diffusion and reaction. In The Fractal Approach to Heterogeneous Chemistry: Surfaces,
Colloids, Polymers , Avnir D (Ed.), Wiley, New York, pp. 251-269, 1989.
Havlin S and D Ben-Avraham, Diffusion in disordered media, Advance in Physics , 36 , 695-798 (1987).
Henke L, N Nagy, and UJ Krull, An AFM determination of the effects of surface roughness caused by cleaning of
fused silica and glass substrates in the process of optical biosensor preparation, Biosensors & Bioelectronics ,
17 , 547-555 (2002).
Johnson T, D Ross, and L Locascio, Rapid microfluidic mixing, Analytical Chemistry , 74 , 45-51 (2002).
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