Binding and Dissociation Kinetics of Different Analytes on Novel Biosensing Surfaces: A Fractal Analysis - Biosensors and Biosensor Kinetics - page 339

Table 12.1: Binding rate coefficients and fractal dimensions for different IgG species to a porous SiO 2 interferometric
biosensor coated with protein A ( Schwartz et al., 2007 ).

Analyte in Solution/
Protein A on a
Porous SiO 2
Interferometric
Biosensor k k 1 k 2 D f D f1 D f2

171 nM human IgG 0.1997 0.0236 0.0911 0.0054 3.6269 0.0779 1.7556 0.0485 0.4984 0.0396 2.5188 0.0503

171 nM rabbit IgG 0.06793 0.0139 0.0215 0.0019 4.350 0.00195 1.5234 0.0923 1.1238 0.0774 2.6090 0.0669

171 nM goat IgG 0.0198 0.00489 0.0050 0.0012 0.1329 0.0028 1.3940 0.1084 0.9260 0.1970 1.9088 0.3298

Table 12.2: Binding and dissociation rate coefficients and fractal dimensions for the binding and the dissociation phase for 51 and
171 nM human IgG in solution to a protein-A coated SiO 2 surface ( Schwartz et al., 2007 ).

Analyte in
Solution k k 1 k 2 k d D f D f1 D f2 D fd

51 nM
human IgG

0.297 0.055 0.09222 0.00559 5.734 0.075 2.7046 0.2362 2.1226 0.1367 1.7524 0.0862 1.7356

0.0387

2.7046
0.2362

171 nM
human IgO

0.0773 0.00066 na na 0.003078 0.000083 0.9796 0.00778 na na 1.0644

0.01621