Biomedical Engineering Reference
In-Depth Information
CHAPTER 12
Binding and Dissociation Kinetics of
Different Analytes on Novel Biosensing
Surfaces: A Fractal Analysis
Chapter Outline
12.1 Introduction
335
12.2 Theory
336
12.2.1 Single-Fractal Analysis
336
Binding Rate Coefficient
336
Dissociation Rate Coefficient
12.2.2 Dual-Fractal Analysis
337
Binding Rate Coefficient
12.1 Introduction
The biosensor field has expanded rapidly over the last few years. Well-tested biosensor tec-
hniques are being applied for the detection of different analytes. However, novel and effec-
tive biosensing techniques are being continuously developed. In this chapter we use the
fractal analysis technique to analyze the binding and dissociation (if applicable) kinetics of
(a) the binding and dissociation of IgG species to a porous SiO
2
interferometric biosensor
coated with protein A (
Schwartz et al., 2007
), (b) binding (hybridization) using differential
surface plasmon resonance (
Boecker et al., 2007
), (c) binding of glucose to a One Touch II
blood glucose meter and a surface-enhanced Raman scattering (SERS) sensor (
Stuart et al.,
2006
), (d) binding of H9 avian virus to cadmium quantum dots (Yun et al., 2007), and
(e) the binding of sodium ions of Na
0.44
x
MnO
2
to a selective sodium ion sensor (
Sauvage
et al., 2007
).
Some of the other novel biosensing techniques that have recently appeared in the literature
and are not analyzed here by the fractal analysis method include: (a) a novel platform for
the oriented buildup of immunoglobulins on a gold surface for a surface plasmon
