Biomedical Engineering Reference
In-Depth Information
0.005
0.004
0.003
0.002
0.001
0
0
10
20
30
40
50
60
Time (s)
Figure 10.14
Binding to a nc-Fe
3
O
4
/Si-NPA (nanocrystal magnetite/silicon nanoporous pillar array)
(
Wang and Li, 2005
).
Wessa et al., 1998
).
Manera et al. (2007)
present an analysis of the sensing properties of
polyimide films by means of the SPR technique for the detection of volatile organic carbons
(VOCs) such as ethanol and methanol. The detection of the vapors of methanol and ethanol
represent a key step in the control of food quality (
Manera et al., 2007
).
Figure 10.15a
shows the binding and dissociation of 3320 ppm methanol in air to a polyimide
thin layer biosensor (
Manera et al., 2007
). A single-fractal analysis is adequate to describe
the binding and dissociation kinetics. The values of (a) the binding rate coefficient,
k
, and
the fractal dimension,
D
f
, for a single-fractal analysis, and (b) the dissociation rate coeffi-
cient,
k
d
, and the fractal dimension for the dissociation phase,
D
fd
, are given in
Tables 10.10
and
10.11
. In this case the affinity,
K
(
ΒΌ
k
/
k
d
) is equal to 0.677.
0.025
0.02
0.02
0.015
0.015
0.01
0.01
0.005
0.005
0
0
0
10
20
30
40
50
60
0
10
20
30
40
50
60
70
A
B
Time (min)
Time (min)
Figure 10.15
Binding and dissociation of different methanol concentrations (in ppm) to a polyimide thin layer
biosensor (
Manera et al., 2006
). Influence of a repeat run: (a) 3320 (b) 3320.
