Biomedical Engineering Reference
In-Depth Information
0.5
1.2
1
0.4
0.8
0.3
0.6
0.2
0.4
0.1
0.2
0
0
0 0 0 0
Bradykinin concentration (nM)
80
100
120
140
0
20
40 60
Bradykinin concentration (nM)
80
100
120
140
A
B
1.2
0.3
1
0.25
0.8
0.2
0.6
0.15
0.4
0.1
0.2
0.05
0
0
1.6
1.8
2
2.2
2.4
2.6
1.2
1.4
1.6
1.8
2
2.2
D
C
Fractal dimension,
D
f2
D
fd2
6
5
4
3
2
1
0.95
1
1.05
1.1
1.15
1.2
1.25
D
f2
/
D
fd2
E
Figure 9.4
(a) Increase in the binding rate coefficient, k
2
with an increase in the bradykinin concentration
(in nM) in solution. (b) Increase in the dissociation rate coefficient, k
d2
with an increase in the
bradykinin concentration (in nM) in solution. (c) Increase in the binding rate coefficient, k
2
with an
increase in the fractal dimension, D
f2.
(d) Increase in the dissociation rate coefficient, k
d2
with
an increase in the fractal dimension, D
fd2.
(e) Increase in the affinity, K
2
(
ΒΌ
k
2
/k
d2
) with an increase
in the ratio of the fractal dimensions, D
f2
/D
fd2.
