Biomedical Engineering Reference
In-Depth Information
in solution to the poly
(guanine)-functionalized silica nanoparticles (NPs) (
Wang et al., 2006
), and (b) the binding of different antigens CD3, CD5, and
CD7 to the antibodies anti-CD3, anti-CD5, and anti-CD7, respectively, immobilized on a plasma-polymerized film (PPF) of
n-butylamine, nanogold particles, and protein A (PA) on a QCM (quartz-crystal microbalance) sensor surface (
Zeng et al., 2006
)
.
Table 8.1: Binding rate coefficients and fractal dimensions for (a) the binding of 1.0 ng/mL TNF-
a
Analyte in Solution/
Receptor on Surface
D
f
D
f1
D
f2
k
k
1
k
2
(a)
1.0 ng/mL TNF-
/
functionalized silica
nanoparticles (NPs)
2.0160
0.2806
na
na
3.381
0.394
na
na
a
(b)
CD7/anti-CD7 on a
QCM surface
1.5688
0.101
1.1436
0.0936
2.8362
0.0363
25.253
4.898
19.275
1.964
154.1
1.54
CD5/anti-CD5 on a
QCM surface
1.3196
0.155
0.8498
0.272
2.3474
0.1249
14.868
4.210
11.074
2.651
62.33
4.93
CD3/anti-CD3 on a
QCM surface
1.5558 0.119
1.0768 0.151
2.4426 0.0943
13.927 3.063
10.081 1.408
46.636 2.852
