Biomedical Engineering Reference
In-Depth Information
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Figure 6.8
Binding of different concentrations of glucose in solution to a disposable biosensor using
electroless-plated Au/Ni/copper low electrical resistance electrodes (
Lee et al., 2008
): (a) 53 mM
(b) 27 mM (c) 21 mM.
Time (s)
Time (s)
Hsu et al.
(
2009a,b,c
)
have recently analyzed the long-term stability of a glucose biosensor
based on inserted barrel plating gold electrodes. These authors point out that glucose one
time strips are regularly used by diabetics to monitor their sugar levels. They report that their
performance varies. They have critically evaluated the performance of the long-term stability
of these strips. They further assert, as indicated elsewhere in this topic, that exact glycemic
control is essential for the control and management of DM (diabetes mellitus). One shot strips
that can be used for determining the glucose levels in blood are cost effective and stable,
and may be mass produced. They also point out that an essential component is fast electron
transfer and good reproducibility. They state further that glucose oxidase is frequently used
in portable glucose sensors. However, in glucose oxidase, the active site is well-embedded
in the enzyme, and direct electron transfer from the active site to the sensing electrodes
is hindered (
Wilson and Turner, 1992; Hecht et al., 1993
). Various strategies have been
