Molecular Recognition of Nucleotides - Designing Receptors for the Next Generation of Biosensors - page 52

Molecular Recognition of Nucleotides

Hannes Y. Kuchelmeister and Carsten Schmuck

Abstract Nucleotides are amongst the most targeted anionic species for artificial
host systems, because they are ubiquitously present in biological systems in which
they exercise key roles in many cellular functions and thus offer interesting
structural features for the benchmarking of designed host systems in supramolecu-
lar chemistry (Voet et al., Fundamentals of biochemistry. Wiley-VCH, Weinheim,
2002). Nucleotides are, for example, involved in DNA synthesis, energy, and
electron transfer events (Nath, Bioenerg Biomembr 42:301-309, 2010), cell signal-
ing (Riedl and Salvesen, Nat Rev Mol Cell Biol 8:405-413, 2007), or membrane
transport (Tojima et al., Nat Rev Neurosci 12:191-203, 2011). These are complex
events which require the molecular recognition of a specific nucleotide. In order to
increase our insight into these processes the development of model systems for
nucleotide recognition is desirable.

Keywords Artificial receptors • Host-guest chemistry • Supramolecular

chemistry • Nucleotides

Contents

1 Nucleotide Recognition in Water . . .......................................................... 54
1.1 Polyamine-Based Receptors . . . . . . ..................................................... 54
1.2 Guanidinium-Based Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
1.3 Calixarene- and Cyclodextrin-Based Receptors . ..................................... 58
1.4 Peptide-Based Receptors . . . ........................................................... 61
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64

H.Y. Kuchelmeister and C. Schmuck ( * )
Institute for Organic Chemistry, University of Duisburg-Essen, Universit atsstr. 7, 45117 Essen,

€

Germany
e-mail: [e-mail]