Learning from Proteins and Drugs: Receptors That Mimic Biomedically Important Binding Motifs - Designing Receptors for the Next Generation of Biosensors - page 35

Fig. 1 (a) Crystal structure of chloride ( green sphere ) bound in the pore of a ClC chloride channel
(PDB 1KPL). Key hydrogen bond contacts are observed with surrounding Ile, Ser, Tyr, and Phe
residues. (b) N- acyl sulfonamide linked dinucleoside mimic bound to RNase A. A key H-bond
between the sulfone of the inhibitor and a nearby histidine is observed in the crystal structure (PDB
2XOI). H-bonds are shown as red lines .(c) Natural dimeric RNA fragment ( left ) and N -acyl
sulfonamide functionalized mimic ( right ). Both compounds are deprotonated at physiological pH
and the mimic displays moderate inhibitory activity against RNase A