Biomedical Engineering Reference
In-Depth Information
5 Summary
On the road to next generation biosensors, the emerging field of transition metal-
modified receptors has significantly evolved over the last decade. Inspired by the
design and function of natural molecular recognition systems, several groups have
constructed novel functional metalloreceptors with high performance characteri-
stics that enhance and/or supplement conventional biomolecules such as proteins,
enzymes, and DNA. In this chapter, three general roles for transition metals were
discussed in the context of synthetic receptors: (1) metal as receptor scaffold,
(2) metal as allosteric receptor for catalysis regulation, and (3) metal as integrated
electroactive reporter. In each case, the versatility of transition metal coordination
chemistry is exploited through rational design. It is anticipated that future work in
these areas will remain a significant research focus.
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