Evolving Trends in Transition Metal-Modified Receptor Design and Function - Designing Receptors for the Next Generation of Biosensors - page 234

Evolving Trends in Transition Metal-Modified
Receptor Design and Function

Paul A. Bertin

Abstract Nature elegantly invokes transition metal ions in a number of fundamental
biomolecular processes from guiding protein folding and scaffolding tertiary
structures to essential roles in information transmission through ligand binding,
electron transfer, and catalysis. Often inspired by such natural systems, innovative
transitionmetal-modified receptors are beginning to emerge with similar functions that
hold substantial promise as components of next generation biosensors. This chapter
aims to highlight some recent advances in the development of transition metal-
modified synthetic receptors. Specifically, systems that incorporate organometallic,
monometallic, and supramolecular coordination complexes are reviewed. The text
will cover transition metal scaffolded peptide receptors, allosteric supramolecular
enzyme mimics, and integrated monolayer-based electroactive receptor systems.

Keywords Allosteric supramolecular systems, Ferrocene bioconjugates,

Metalloreceptor

Contents

1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 240
2 Transition Metal Complexes as Scaffolds in Receptor Design . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
2.1 Metal-Directed Peptide Assemblies for Molecular Recognition . ................... 242
2.2 Metalloreceptor Scaffolds in Differential Sensing . . . ............................... 244
3 Functional Allosteric Supramolecular Receptors . ......................................... 245
4 Monolayer Receptors with Integrated Metal-Based Reporters ............................ 250
4.1 Ferrocene-DNA Conjugates . ........................................................ 251
4.2 Peptide-Functionalized Metalloreceptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 252
5 Summary . . .................................................................................. 256
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 256

P.A. Bertin ( * )
Ohmx Corporation, 1801 Maple Avenue, Suite 6143, Evanston, IL 60201, USA
e-mail: [e-mail]