Biomedical Engineering Reference
In-Depth Information
competitively interact with glucose was based on our evaluation of the Keq of a
DBA for a diol versus the Keq of the DBA for glucose. A binding affinity model
based on a three-component (DBA:diol:glucose) competitive assay was used to
generate a scatter plot of interaction data. Based on the location of a representative
data point on the interaction graph, the response of glucose and/or each diol for each
DBA was evaluated for inclusion into the iDIOL screening process, which more
closely mimic the format of the final device. The glucose sensing system described
here provides a foundation for the integrated development of the final implantable
device.
Acknowledgments We thank PositiveID Corporation for their partial financial support for this
project.
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