Design and Development of In Vivo Sensor Systems: The Long and Tortured Road to a Self-Contained, Implantable Glucose Sensor for Diabetes Management - Designing Receptors for the Next Generation of Biosensors - page 227

a b

OH

OH

HO

HO

O

O

HO

HO

NH

O

C

NH NH

c d

OH

OH

HO

OH

O

H O

C

NH

Fig. 13 Chemical structures of iDIOL 1 (a), iDIOL 2 (b), iDIOL 3 (c), and DBA 3 and (d)
evaluated for binding performance in a glucose competition binding assay

1.5

Fructose
Glucose
Galactose

1.0

0.5

0.0

[Saccharide] mg/dL

Fig. 14 Glucose, fructose, and galactose competition curves showing the normalized fluorescence
intensity of DBA 3 versus saccharide concentration in a physiological buffer at neutral pH on an
iDIOL 3 surface