Molecularly Imprinted Au Nanoparticle Composites for Selective Sensing Applications - Designing Receptors for the Next Generation of Biosensors - page 184

Molecularly Imprinted Au Nanoparticle
Composites for Selective Sensing Applications

Ran Tel-Vered and Itamar Willner

Abstract In this study, a new method to imprint molecular recognition sites into Au
nanoparticles (NPs) composites is described. The method includes the electropoly-
merization of thioaniline-functionalized Au NPs in the presence of imprint substrates
that exhibit affinity interactions with the thioaniline-functionalized Au NPs or with a
co-added ligand associated with the electropolymerizable NPs. Exclusion of the
imprint substrate from the composite leads to the formation of selective imprinted
sites in the Au NPs matrices. The imprinted matrices are implemented for the sensing
of explosives, herbicides, saccharides, and ions.

-Donor-acceptor interactions, ionic
interactions and H-bonds, or ligand-substrate interactions are used to generate the
imprinted sites. The coupling between the localized plasmon of the NPs and the
surface plasmon wave of the support is used to amplify the dielectric changes
occurring in the NPs matrices upon the binding of the analytes to the imprinted
sites, thus enabling the surface plasmon resonance (SPR) transduction of the sensing
events. The imprinted Au NPs matrices demonstrate highly selective, stereoselective,
and chiroselective sensing performance.

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Keywords Electropolymerization, Molecular imprinting, Nanoparticles, Sensors,
Surface plasmon resonance

Contents

1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190
2 Molecularly Imprinted Bis-Aniline-Cross-linked Au NPs Matrices for Sensing ......... 191
2.1 Molecular Imprinting of Recognition Sites in Au NPs Composites Through
Donor-Acceptor Interactions ......................................................... 195

2.2 Ionic Interactions in Molecularly Imprinted Au NPs Matrices for Sensing . . . ..... 199

R. Tel-Vered and I. Willner ( * )
The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
e-mail: [e-mail]