MIP Sensors on the Way to Real-World Applications - Designing Receptors for the Next Generation of Biosensors - page 179

Fig. 9 AFM image of erythrocytes imprinted polymer surface

catalyst to derivatize D / L -homocysteine with N -(1-pyrenyl)maleimide. The product
of this reaction served as the template during imprinting. The derivatization step
introduces a fluorescent group into the homocysteine molecule. Therefore fluores-
cent measurements directly at the MIP allowed for determination directly in blood
plasma.

5 Commercially Available MIPs for Analytical Applications

As already mentioned, MIPs have substantial application possibilities in the fields
of separation, catalysis, biomimetic assays, and sensors [ 12 , 58 , 59 ]. However, the
number of MIPs in commercial production still lags behind the expectations from
laboratory experience. Nonetheless, there are a number of companies that have
introduced MIP-based products for a range of applications, including sensing, on a
commercial basis [ 58 ]. For example MIP Technologies, which is now part of
Biotage ( http://www.biotage.com ), have commercialized products such as
“MIP4SPE ® ” for solid phase extraction, “MIP4LC ® ” used for HPLC and
“MIP4Discovery ® ” for drug screening. Together with Supelco ( http://www.
sigmaaldrich.com ) they are also selling a product named “SupelMIP

SPE” for
solid phase extraction. Furthermore, Biotage has commercialized a selection of
MIP-based materials named “AFFINILUTE MIP products” used for solid phase
extraction (SPE) analysis of chloramphenicol,

™

tobacco-specific nitrosamine

derivatives, NNAL, triazines, clenbuterol, -blockers. Chrysalis

Scientific Technologies Inc. is marketing MIPs for solid phase extraction (MIP[4]

-agonists, and

b b