MIP Sensors on the Way to Real-World Applications - Designing Receptors for the Next Generation of Biosensors - page 163

MIP Sensors on the Way to Real-World
Applications

Ghulam Mustafa and Peter A. Lieberzeit

Abstract Molecularly imprinted polymers are mostly confined to laboratories and
their standardized environments. Chemical sensors based on MIP are no exception
to this; however, there are increasing efforts to span the gap toward technological
applications and thus exposing the devices to real-life environments and thereby
assessing selectivity, sensitivity, and ruggedness of the respective sensors. In some
application areas this has already been successful, namely in detecting volatile
organics and their mixtures, sensing pesticides in environmental water samples, in
assessing oxidation processes, e.g., in engine oils, and in some applications of
bioanalysis targeting both signaling molecules/drugs and whole cells, viruses, or
bacteria. Here, we summarize the selected aspects for transferring MIP strategies
out from lab-bench conditions and highlight some of the successful examples.

Keywords MIP biosensing, MIP sensor materials, Oxidative degradation,
Pesticides, Real-life matrices, Sensor arrays, Volatile organics

Contents

1 Molecular Imprinting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
2 Molecular Imprinting Strategies ............................................................ 170
2.1 Bulk Imprinting ....................................................................... 170
2.2 Surface Imprinting . . .................................................................. 171
2.3 Imprinted Nanoparticles . . . . . . . ....................................................... 172
3 Molecular Imprinting in Chemical Sensing ................................................ 172
4 Real-Life Applications of MIP ............................................................. 176
4.1 MIP Sensors in Multicomponent Environments . .................................... 177
4.2 Pesticide MIP Sensors as an Example of Environmental Sensing . . . . . . . . . . . . . . . . . . 179
4.3 MIP Sensors Applications in Biosensing . . . ......................................... 181

G. Mustafa and P.A. Lieberzeit ( * )
University of Vienna, Department of Analytical Chemistry, W ahringer Strasse 38, 1090,

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Vienna, Austria
e-mail: [e-mail]