Biomedical Engineering Reference
In-Depth Information
Multichannel Sensors Based on Biphenyl and
Cyclohexane Conformational Changes
Ana M. Costero, Margarita Parra, Salvador Gil, and M. Rosario Andreu
Abstract Conformational changes as a transduction mechanism are considered in
both biphenyl- and cyclohexane-based chemosensors. The sensors under study have
been designed by following the binding site-signaling unit approach. Modifications
in the dihedral angle of the biphenyl and bipyridine system induced by complexa-
tion with target molecules can give rise to major changes in the sensor's UV-Vis,
fluorescence, and electrochemical properties. This behavior has been used to detect
both cations and anions in different solvents. 1,2,4,5-Tetrasubtituted cyclohexane
derivatives with a trans-transoid-trans configuration and appropriate binding sites
have also been used in carboxylate and dicarboxylate sensing. Diastereoisomeric
and enantiomeric selectivity has been explored in addition to the discrimination
between
a
,
o
-dicarboxylates of different lengths.
Keywords Anion, Biphenyl, Cation, Chemosensor, Cyclohexane, Fluorescence
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
2 Biphenyl Derivatives ......................................................................... 3
2.1 Recognition and Sensing of Cations . . ................................................ 3
2.2 Recognition and Sensing of Anions . .................................................. 19
3 Cyclohexane Derivatives in Anion Recognition . . . . . ....................................... 25
4 Final Remarks . . . ............................................................................. 29
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
A.M. Costero ( * ), M. Parra, S. Gil, and M.R. Andreu
Centro de Reconocimiento Molecular y Desarrollo Tecnol´gico (IDM), Unidad Mixta
Universidad de Valencia-Universidad Polit´cnica de Valencia, Doctor Moliner 50, 46100
Burjassot, Valencia, Spain
e-mail: ana.costero@uv.es
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