Biomedical Engineering Reference
In-Depth Information
Folate receptor
O
HO
O
O
N
N
Blood vessel
Nucleus
O
O
O
O
N
H
OH
O
O
N
H
N
H
2
N
H
2
N
Cl
Cl
Pi
N
NH
2
N
O
O
H
O
Folate receptor
Folic acid
Pt
IV
prodrug
HO
O
O
O
N
N
O
O
O
O
H
OH
O
O
N
H
N
H
3
N
Cl
1
Pt
Cl
N
N
NH
2
H
3
N
O
O
HO
O
FIGURE 20.4
The “longboat” anticancer system in which the chemotherapeutic agent cisplatin is attached from one end to the FA derivative and from
the opposite end to a SWNT via an amide link.
From
[15]
.
