Biomedical Engineering Reference
In-Depth Information
Table 14.2
Research Reports of BMP-2 Release for Ectopic Bone Formation
Material
Implanted Site
Animal
Inorganic material
β
-TCP (tricalcium phosphate)
Muscle
Mouse
HAp (hydroxyapatite)
Muscle
Rat
Plaster of Paris
Muscle
Mouse
Organic material
IBM (insoluble bone matrix)
Muscle
Mouse
Type I collagen
Muscle
Rat
Fibrin glue
Muscle
Mouse
PLA (polylactide)
Muscle
Mouse
PLGA (poly(lactide-
co
-glycolide))
Muscle
Mouse
PLA-PEG (poly(lactide-coethylene glycole)
Muscle
Mouse
Gelatin hydrogel
Muscle
Rat
FIGURE 14.4
Representative of tissue appearance (A, B, and C) and histological cross-sections (D, E, and F) of
ectopically formed bone after subcutaneous injection of TGF-
β
(A and D), peptide solution (B and E), and
peptide solution with TGF-
β
(C and F). The concentration of TGF-
β
is 10
μ
g. Each specimen subjected to
H-E staining. Arrow indicates the newly formed bone.
tissue and the release bFGF induced significant angiogenesis around the injected site when compared
to bFGF or PA injections alone. This release system also induced significant bone formation when
peptide amphiphile solutions and TGF-β were subcutaneously injected to the back of rat as shown in
Figure 14.4
. The injected solutions of peptide and TGF-β formed solid gel and the sustained release
