Biomedical Engineering Reference
In-Depth Information
showed excellent biocompatibility with stem cells. hUCMSCs and hBMSCs attached to these scaf-
folds and successfully differentiated down the osteogenic lineage. The nano-apatite-fiber scaffold
morphologically mimicked the extracellular matrix of natural bone and supported stem cell attach-
ment and function. Potential applications include the major reconstructions of the maxilla, mandible,
and other craniofacial restorations, bone regeneration after trauma or tumor resection,
in situ
fracture
fixation, and the filling and strengthening of osteoporotic bone lesions at risk for fracture. All these
applications could benefit from a self-setting, biomimetic nano-apatite scaffold/stem cell construct
with enhanced fracture and fatigue resistance, and rapid bone regeneration capability. Further stud-
ies are needed to investigate the
in vivo
bone regeneration efficacy of this new class of nano-apatitic
composite scaffold/stem cell constructs.
Acknowledgments
We thank Drs L.C. Chow, S. Takagi, and A.A. Giusseppetti at the Paffenbarger Research Center, and
Dr John Fisher at the University of Maryland for discussions and help. This study was supported by
NIH R01 grants DE14190 and DE17974 (HX), Maryland Stem Cell Research Fund (HX), and the
University of Maryland Dental School.
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