Biomedical Engineering Reference
In-Depth Information
CHAPTER
11
Fabrication of PEG Hydrogel
Micropatterns by Soft-
Photolithography and PEG
Hydrogel as Guided Bone
Regeneration Membrane in
Dental Implantology
K. Subramani
1
and W. Ahmed
2
1
Department of Orthodontics, University of Kentucky, Lexington, KY, USA
2
Institute of Nanotechnology and Bioengineering, School of Computing, Engineering and Physical Sciences,
University of Central Lancashire, Preston PR1 2HE, UK
CONTENTS
11.1 Introduction ..................................................................................................................................172
11.2 Microfabrication ...........................................................................................................................172
11.2.1 Microfabrication Techniques.................................................................................. 173
11.2.1.1 Property Modification .......................................................................................
173
11.2.1.2 Microfabrication by Patterning..........................................................................
173
11.2.1.3 Additive Microfabrication..................................................................................
173
11.2.1.4 Subtractive Microfabrication .............................................................................
173
11.3 Lithography...................................................................................................................................174
11.4 Hydrogel as a Biomaterial .............................................................................................................174
11.5 Soft-Photolithography of Hydrogel Micropatterns ............................................................................175
11.5.1 Fabrication of PDMS Stamp .................................................................................. 175
11.5.1.1 Design of the Photomask..................................................................................
175
11.5.1.2 Fabrication of “Master” or Negative Mould .......................................................
175
11.5.1.3 Fabrication of PDMS ........................................................................................
175
11.5.2 Surface Functionalization of Silicon Substrates by Silanization................................. 177
11.5.3 Soft-Photolithography ........................................................................................... 178
11.6 PEG Hydrogel as GBR Membrane in Dental Implantology..................................................................184
11.7 Conclusions..................................................................................................................................185
Acknowledgments..................................................................................................................................185
References ............................................................................................................................................185
