Biomedical Engineering Reference
In-Depth Information
Table 8.4
Tissue Responses Toward Surface-Modified Ti and its Alloys
in vivo
[41]
Implant materials
Modiication
Animal Models
Tissue Responses
References
Ti, screw-shaped
implants
Blasting with TiO
2
, HF
treatment, nano-HA
Rabbit
Increased removal
torque values
Demonstrated bone
formation in contact with
the implant surface
[108]
Ti implants
HA deposition by
IBAD, SLA Ti implants
Machined assisted
implants
Rabbit, dog
Highest mean bone-to-
metal contact ratio in
HA-modified Ti implants
Increased osseoactivity
[109-111]
Very smooth Ti
implants
Nano-HA modification
Rabbit
Similar bone formation
for untreated Ti and
nano-HA Ti implants
[112]
Electropolished Ti
implants
Nano-HA (10 nm in
diameter) modification
Rabbit
Increased bone
formation in nano-HA Ti
implants
Higher bone-to-implant
contact for E-HA Ti
implants compared to E
Ti implants
[113]
Ti implants
Laser ablation
followed by nano-HA
deposition
Rabbit
Shorten implant healing
Increased bone implant
interactions
[114]
Ti cylinder implants
HA or titania
nanostructures
Rabbit
Increased coverage
area and feature density
in nanotitania-coated
implants
Higher bone
contact values (but
not significant) for
nanotitania implants
[115]
Ti implants
Calcium
metaphosphate
coated, anodic
oxidized, HA
deposition
Rabbit
Superior bone
responses in all surface-
modified implants
Higher bone contact
values
[116,117]
SLA titanium
implants
Ti coated with
calcium phosphate,
Ti modified via anodic
plasma-chemical
treatment (APC),
bisphosphonate-
coated Ti
(Ti Bisphos), and Ti
coated with collagen
containing chondroitin
sulfate
Sheep
Surface Ti implants with
bisphosphonate and
collagen enhanced peri-
implant bone formation
[118]
SLA zirconia
implants
(
Continued
)
