Biomedical Engineering Reference
In-Depth Information
Table 8.3
(Continued)
Modified
Structures/
Chemicals
Modification
Methods
Materials
Used
Cell Type
Cell Responses
References
Micro-/
Nanotopography
Hydroxyapatite
(HA)/SLA by the
ion beam assisted
deposition (IBAD)
HA particles
hMSC
Induced adhesion
[96]
Increased levels of ALP,
OCN
Improved cell
proliferation and
differentiation
7, 15, 40 nm
Sol-gel coating
Nobium
oxidation
MC3T3-E1
Optimal cell adhesion
and spreading at 15 nm
[97]
Surface
chemistry with
Mg, Zn, CHAP
Ion beam
implantation
Zinc,
magnesium,
alkoxide-
derived
hydroxy
carbonate
apatite
(CHAP)
Human
osteoblasts
Upregulated c-fos, MAP
kinase pathways
[98]
60-70 nm
thickness
Surface
chemistry with Ti
alloys
Pulsed laser
deposition
Ti6Al4V,
TiNb30, and
TiNb13Zr13
Osteoblast-
like cells
Had positive effect on
cell alignment
[99]
Influenced focal contact
formation
Surface
chemistry with
metals
Compaction
Ti, Ti6Al4V,
CoCrMo
Human
osteoblasts
Increased cell adhesion
[24]
Surface
chemistry with
HA, tricalcium
phosphate
(TCP), calcium
titanate (CaTiO3)
Ti coating/
annealing
HA, TCP,
CaTiO
3
Human
osteoblasts
Enhanced cell adhesion
for CaTiO
3
, the most
enhanced adhesion for
TCP/CaTiO
3
[100,101]
Surface
chemistry with
RGD
H
2
O
2
treatment/
adsorption
RGD
RMSC
High efficiency of RGD
attachment
[35]
Rat calvarial
osteoblasts
[57]
Calcified matrix
formation
Enhanced cell adhesion
Surface
chemistry with
alumina, titania,
HA
Compaction
Alumina,
titania, HA
powders
Rat
osteoblasts
Increased vitronectin
adsorption
[102]
Induced cell adhesion
Surface
chemistry with
functional (e.g.,
carboxylic acid)
groups
Grafting Ti with
polymers
Pyrrole-3-
acetic acid,
chitosan
Mouse
bone
marrow
cells
Enhanced protein
binding
[54,63]
Induced cell attachment,
proliferation, and ALP
activity
(
Continued
)
