Biomedical Engineering Reference
In-Depth Information
Table 8.3
Cellular Responses Towards Surface-Modified Titanium and its Alloys
Modified
Structures/
Chemicals
Modification
Methods
Materials
Used
Cell Type
Cell Responses
References
30-100 nm
nanotubes
Anodization
Titanium
dioxide
(TiO
2
)
hMSC,
hSaOS-2
Enhanced adhesion for
30 nm
Induced ALP production,
elongated morphology,
differentiation for
70-100 nm
[75-79]
30-100 nm
nanotubes
Anodization
TiO
2
BAEC
Enhanced focal
adhesions
Upregulated
antithrombotic cellular
state (e.g., induced nitric
oxide, endothelin-1)
[76]
Nanotubular
Anodization
Titania
RMSC
Enhanced cell adhesion,
proliferation, ALP activity,
bone matrix deposition
[80]
15, 55, and
100 nm
nanopillars,
15-140 nm
dot-, pillar-like
structures
Anodization
through a porous
alumina mask
Titania (or
TiO
2
)
hMSC
Enhanced bone matrix
nodule forming (15 nm)
[81,82]
Nanofibers
Surface coating
Silicon (Si),
silicon oxide
(SiO
2
), and
titanium
oxide (TiO
2
)
MC3T3-E1
Better cell proliferation
for Si, SiO
2
fibers
Higher cellular
differentiation for TiO
2
fibers
[83]
8-10 nm
roughness
DC reactive
magnetron
sputtering
Titania
Primary rat
osteoblasts
Enhanced cell adhesion,
spreading, proliferation,
and differentiation
[84]
30-50 nm
roughness
Electrolytic
deposition
TiO
2
Primary rat
osteoblasts
Enhanced cell adhesion,
spreading, proliferation
[85]
110 nm
hemispherical
Electrostatic
interactions of
adsorbed colloidal
particles
TiO
2
Primary
human
osteoblasts
No difference in
cell adhesion and
cytoskeletal formation
Accelerated PGE2
release
Increased fiber length of
F-actin and
β
-tubulin
[86]
Nanotopography
Acid treatment
H
2
SO
4
/H
2
O
2
Rat calvarial
osteoblasts
Induced cell proliferation,
ALP activity
Favored BSP,
osteopontin, fibronectin
accumulation
[87]
(
Continued
)
