Biomedical Engineering Reference
In-Depth Information
Chapter 13
Practical Issues on Using Weighted
Logrank Tests with
Trials
Michael P. Fay and Sally A. Hunsberger
National Institute of Allergy and Infectious Diseases, National Cancer Insti-
tute, Bethesda, Maryland, USA
13.1
Introduction :::::::::::::::::::::::::::::::::::::::::::::::::::::: 346
13.2
Description of Interval-Censored Data and Assumptions for
Testing ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: 346
13.2.1
Overview ::::::::::::::::::::::::::::::::::::::::::::::::: 347
13.2.2
Basic Notation ::::::::::::::::::::::::::::::::::::::::::: 348
13.2.3
Assessment of Simple Endpoints :::::::::::::::::::::::: 349
13.2.4
Composite Endpoints and Interval Censoring ::::::::::: 351
13.2.5
Informative Assessment ::::::::::::::::::::::::::::::::: 352
13.3
Rank Tests for Interval-Censored Data :::::::::::::::::::::::::: 353
13.3.1
Overview ::::::::::::::::::::::::::::::::::::::::::::::::: 353
13.3.2
Practical Proposal: Ignoring Unscheduled Assessments : 354
13.3.3
Likelihood for Grouped Continuous Model ::::::::::::: 355
13.3.4
Permutation-Based Rank Tests ::::::::::::::::::::::::: 357
13.3.5
Score Tests with a High-Dimensional Nuisance
Parameter :::::::::::::::::::::::::::::::::::::::::::::::: 359
345
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