Dental and Skeletal Applications of Silica-Based Nanomaterials - Nanobiomaterials in Clinical Dentistry - page 80

ideal compound for a number of dental purposes. Potential applications include filler as a key con-
stituent of composites, an abrasive to polish and reduce bacterial attachment, as well as a delivery
vehicle for antimicrobials. Recent studies also suggest that silica nanoparticles hold the potential to
influence cell types in the tooth and possibly gum. If silica-based nanomaterials will be used in the
context of an active biological agent to influence cells, a toxicology profile will need to be estab-
lished and the environmental impact of nanoparticles, which is still not fully understood, will need
to be carefully assessed.
Acknowledgments
The authors are supported by grants from the NIH/NIAMS (AR056090), Georgia Research Alliance (GRA.
VL12.C2), and the Emory Center for Pediatric Nanomedicine. MNW is also supported in part by funding from
the Biomedical Laboratory Research and Development Service of the VA Office of Research and
Development (5I01BX000105) and by grants AR059364 and AR053607 from NIAMS, and AG040013 from
NIA. GRB is also supported in part by grants from the NCI (CA136059 and CA136716).
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