Orally Delivered Nanoparticle Drug Delivery Systems for Dental Applications and Their Toxicity on Systemic Organs - Nanobiomaterials in Clinical Dentistry - page 467

CHAPTER
24

Orally Delivered Nanoparticle
Drug Delivery Systems for
Dental Applications and Their
Toxicity on Systemic Organs

Yashwant Pathak a and Charles Preuss b
a College of Pharmacy, University of South Florida, Tampa, Department of Pharmaceutical Sciences, FL, USA
b Department of Molecular Pharmacology and Physiology, Morsani College of Medicine,
University of South Florida, Tampa, FL, USA

CHAPTER OUTLINE

24.1 Introduction ............................................................................................................................... 497
24.2 Dental applications of nano drug delivery .................................................................................... 499
24.2.1 Nanoparticulate drug delivery systems local anesthesia............................................ 499
24.2.2 Curing the hypersensitivity in oral treatments.......................................................... 500
24.2.3 Nanorobotic dentifrices......................................................................................... 500
24.2.4 Dental durability and cosmetics applications in dentistry ......................................... 501
24.2.5 Nanophase alumina for dental applications............................................................. 501
24.2.6 Nanoparticulate drug delivery in dental applications ................................................ 501
24.2.7 Treatment of oral cancer using nanoparticulate drug delivery system......................... 502
24.3 Toxicity of nanoparticles ............................................................................................................ 502
24.3.1 Toxicokinetics ...................................................................................................... 503
24.3.2 Acute and chronic toxicity ..................................................................................... 504
24.3.3 Genotoxicity and carcinogenicity............................................................................ 505
24.3.4 Reproductive and developmental toxicity ................................................................ 505
24.4 Conclusions............................................................................................................................... 506
References ......................................................................................................................................... 506

24.1 Introduction
The unprecedented growth of nanosciences [1 4] in every walk of life has created lots of optimism

in nano applications for medicine and the field of dentistry is not lagging behind in the race.