Biomedical Engineering Reference
In-Depth Information
clinical and radiographic analysis, it was determined that significant alveolar ridge width gain
occurred with the material providing an appropriate site for placement of a primary
stable implant. The histological assessment of the action of nano-HA material in this study was
fairly consistent with studies of the material in various animal models such as the critical size
calvarial defect in the adult domestic pig and metaphyseal defects in the Gottinger Minipig
[14]
.
Although in the pig calvarial defect model it was reported that complete resorption of the nano-
sized material occurred after 12 weeks
[13]
, in the Gottinger Minipig metaphyseal model, there
was still incomplete resorption after 1 year despite a period of robust resorption during the first
(A)
(B)
(C)
(D)
FIGURE 19.3
Overview of treatment course with nano-HA for lateral ridge augmentation. (A) A full-thickness flap was
elevated and the augmentation area of future implant sites for replacement of the left mandibular second
premolar and the first and second molars was prepared with additional cortical perforations. (B) The titanium
mesh was fixed and the nano-HA bone substitution material is in place. (C) After elevating a full-thickness
flap at reentry 6 months post augmentation, a dense hard tissue gain was found with a thin layer of soft
tissue directly underneath the titanium mesh. (D) After removal of the titanium mesh, a gain in alveolar ridge
width due to defect regeneration by hard tissue formation was noted.
Figure from Ref.
[15]
with permission from publisher.
