Titania Nanotube Coatings on Dental Implants with Enhanced Osteogenic Activity and Anti-Infection Properties - Nanobiomaterials in Clinical Dentistry - page 334

MSC attachment and spread and induce MSC osteogenic differentiation. In addition, the NT Zn

samples also exhibit excellent antibacterial effects to prevent bacterial colonization.

17.6 Conclusions
Many reports have revealed the effectiveness of NTs in promoting the functions of osteoblasts and
MSCs and MSC osteogenic differentiation in vitro and enhancing implant osseointegration in vivo.
Our studies demonstrate the suitability of the NTs to load and deliver some inorganic bioactive
agents such as Ag, Sr, and Zn to achieve antibacterial- and/or osteogenesis-inducing abilities. The
NT surfaces, especially those loaded with suitable inorganic bioactive agents, have huge promise in
fabricating dental implants with better clinical performance.

Acknowledgments
This work was jointly supported by National Natural Science Foundation of China Nos. 50902104 and
31200716, City University of Hong Kong Applied Research Grant (ARG) No. 9667066, and the Opening
Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure (SKL201103SIC).

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