Biomedical Engineering Reference
In-Depth Information
CHAPTER
17
Titania Nanotube Coatings on
Dental Implants with Enhanced
Osteogenic Activity and
Anti-Infection Properties
Lingzhou Zhao
c
, Kaifu Huo
a
,
b
and Paul K. Chu
b
a
School of Materials and Metallurgy, Wuhan University of Science and Technology, Wuhan, China
b
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon,
Hong Kong, China
c
Department of Periodontology and Oral Medicine, School of Stomatology,
The Fourth Military Medical University, West Changle Road, Xi'an, China
CHAPTER OUTLINE
17.1 Introduction ............................................................................................................................... 337
17.2 Fabrication of NTs on Ti ............................................................................................................. 339
17.3 Factors influencing the bioactivity of the NTs .............................................................................. 340
17.3.1 Influence of sterilization on the bioactivity of the NTs .............................................. 340
17.3.2 Influence of cell phenotype on the bioactivity of the NTs.......................................... 342
17.3.3 Influence of protein concentration in culture medium on the bioactivity of the NTs .... 342
17.3.4 Influence of protein distribution pattern on the bioactivity of the NTs........................ 344
17.4 In vitro bioactivity of the NTs and in vivo osseointegration ........................................................... 346
17.4.1 In vitro bioactivity of the NTs................................................................................. 346
17.4.2 In vivo osseointegration of the NTs ......................................................................... 348
17.5 Drug-loading NTs for better bioactivity and antibacterial properties .............................................. 350
17.6 Conclusions............................................................................................................................... 355
Acknowledgments ............................................................................................................................... 355
References ......................................................................................................................................... 355
17.1
Introduction
Dental implants are an ideal option for people in good general oral health who have lost a tooth or
teeth due to periodontal disease, an injury, or some other reasons. Titanium (Ti) and its alloys are
