Biomedical Engineering Reference
In-Depth Information
Table 10.2
Studies Presenting Data on Effects of Nanoparticles Against Oral Microorganisms
Study
Design
Nanoparticles/
Materials Used
Parameters
Studied
Microbial Flora
Studied
Study
Results
[41]
In vitro
Metals/metal oxides
Antimicrobial
activity
Bactericidal
in the range
0.025
2.5 mg/mL
P. gingivalis,
F. nucleatum,
Prev. intermedia, A.
actinomycetemcomitans
[74]
In vitro
Composite adhesives
with silver
nanoparticles
Physical
properties and
antimicrobial
activities
Antiadhesive
properties and
growth retardation
S. mutans, S. sobrinus
[75]
In vitro
Zinc oxide
nanoparticles blended
with resin-based
dental composite
Antibiofilm activity Inhibition of biofilm
growth with
concentration
.
S. sobrinus
10% w/w
[77]
In vitro
Composite resin with
quaternary ammonium
polyethylenimine
nanoparticles
Antibiofilm activity Inhibition of biofilm
formation at 1 and
24 h
S. mutans
[81]
Ex vivo
Zinc oxide/chitosan
nanoparticles
Antiadherence on
treated root canal
surfaces
Antiadherent
E. faecalis
[83]
Ex vivo
Silica nanoparticles
Antiadherence on
polished teeth
surfaces
Antiadherent
S. mutans
[84]
In vitro
Silica nanoparticles
deposited onto
polystyrene surfaces
Development of
biofilm and
invasive filament
formation
Decreased
attachment and
growth
C. albicans
[85]
In vitro
Nitric oxide-releasing
nanoparticles
Antibiofilm activity
.
99% killing
within biofilm
C. albicans
[86]
In vitro
Nanometric bioactive
glass
Antimicrobial
activity in
simulated body
fluid
Significant killing
effects
E. faecalis
[92]
In vitro
and
in vivo
Casein
phosphopeptide
Anticariogenic
Reduction of
colonization
S. mutans
amorphous calcium
phosphate
nanocomplex
received particular attention as a result of their durability. Although certain nanoparticles may be
toxic to oral and other tissues, the surface characteristics of a given particle will help to determine
whether or not it will have potential for oral applications. Approaches to alter biocompatibility and
desired function are now being identified and these include changing the ability to aggregate, appli-
cation of surface coatings, and altering oxidative state and charge density.
