Biomedical Engineering Reference
In-Depth Information
transmucosal routes, buccal mucosa has excellent accessibility, an expanse of smooth muscle, and
relatively immobile mucosa, and hence suitable for administration of retentive dosage forms. Direct
access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic
first-pass metabolism leading to high bioavailability. Other advantages such as low enzymatic
activity, suitability for drugs or excipients that mildly and reversibly damages or irritates the
mucosa, painless administration, easy drug withdrawal, facility to include permeation enhancer/
enzyme inhibitor or pH modifier in the formulation, and versatility in designing as multidirectional
or unidirectional release systems for local or systemic actions opt buccal adhesive drug delivery
systems as a promising option
[82]
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