Biomedical Engineering Reference
In-Depth Information
Figure 6.
Effect of
IPT
1 gene on
C. albicans
interaction with engineered human oral
mucosa. Tissue was exposed to different
C. albicans
strains and histological analyses
were performed. Non-infected tissue (a), the parental
C. albicans
strain (b), the revertant
strain (c) and the
Ipt
1 mutant strain (d). Representative photographs of two different
experiments are shown.
(Color image of this fi gure appears in the color plate section at the end of the topic.)
the plasma membrane of
S. cerevisiae
yeast (Hechtberger et al. 1994) and
supposedly serve as targets for these drugs in the extracellular region
(Thevissen et al. 2000).
Similar to
S. cerevisae
, complex sphingolipids, such as inositol
phosphoceramide (IPC), mannosyl inositol phosphoceramide (MIPC) and
mannosyl-diinositolphosphoceramides (M(IP)2C), are largely produced by
C. albicans,
particularly on the hyphal form (Wells et al. 1996). IPC synthetase
acts as an inositol phosphoryl transferase by catalyzing the transfer of the
phosphoinositol head group of phosphatidylinositol to the C1-hydroxyl
